Eminem - Superman Lyrics Meaning

I believe this is calling out whore-ish type behavior in women. From Eminem's point of view his ex-cheated on him, and he doesn't want to invest and hurt from a hoe or people who are just out to get with him because of fame/sex/money/just having someone to show off to their friends. He plays along with their games but cuts them out of his life because he knows they are just lying whores, I think this song can be for both genders, though it's from males POV. There are some men who are like this too. He is also suggesting he can't save anyone from being a "hoe" it is a choice they made, and they will have to deal with because he knows these type of women who do such things.